Concentration of Transforming Growth Factor β2 in Aqueous Humor
| Autor: | Kiyoyuki Majima, Koichiro Itonaga, Tohru Marunouchi, Naoki Yamamoto |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
genetic structures biology business.industry Glaucoma Aqueous humor General Medicine Diabetic retinopathy Transforming growth factor beta Axial length medicine.disease eye diseases Sensory Systems Cellular and Molecular Neuroscience Ophthalmology Cataracts Diabetes mellitus medicine biology.protein sense organs business Transforming growth factor |
| Zdroj: | Ophthalmic Research. 37:29-33 |
| ISSN: | 1423-0259 0030-3747 |
| DOI: | 10.1159/000083019 |
| Popis: | The total transforming growth factor (TGF) β2 concentration in the anterior chamber aqueous humor of 96 cataract patients with ages ranging from 17 to 88 years was measured using ELISA to investigate the changes that occur with age, difference of axial length, difference of localization of opacification of the cataractous lens and complications with other eye diseases. It was found that the total TGF-β2 concentration (1) decreases with age, (2) shows slight changes with axial length, (3) has slight changes with difference of localization of opacification, (4) is significantly high in patients with concurrent open-angle glaucoma (p < 0.05), (5) is high in patients with complicating diabetes who have undergone panretinal photocoagulation for diabetic retinopathy (p < 0.05) and (6) is low in patients with atopic cataracts. There have been several reports on point 4 above, but none to date of the other points. These findings provide useful information on the intraocular activity of TGF-β2. |
| Databáze: | OpenAIRE |
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