Characterization of a Putative Hemagglutinin Gene in the Caprine Model for Brucellosis

Autor: Lauren Duhon, Sue D. Hagius, Joel V. Walker, Quinesha L. Perry, Philip H. Elzer
Rok vydání: 2010
Předmět:
Zdroj: Emerging and Endemic Pathogens ISBN: 9789048196364
Popis: With the completion of the genomic sequences of Brucella melitensis 16M and B. abortus 2308 and the vaccine strain RB51, a putative hemagglutinin gene was identified that is present in 16M and absent in B. abortus. The possibility of this hemagglutinin being a potential host specificity factor was evaluated via expression in trans in B. abortus 2308-QAE and RB51-QAE. Using the caprine brucellosis model, colonization and pathogenesis studies were performed to evaluate the strains.
Databáze: OpenAIRE