Long-term outcome of cardiac resynchronization therapy patients in the elderly

Autor: Anett Behon, Eperke Dóra Merkel, Walter Richard Schwertner, Luca Katalin Kuthi, Boglárka Veres, Richard Masszi, Attila Kovács, Bálint Károly Lakatos, Endre Zima, László Gellér, Annamária Kosztin, Béla Merkely
Rok vydání: 2023
Předmět:
Zdroj: GeroScience.
ISSN: 2509-2723
2509-2715
Popis: Heart failure (HF) is a leading cause of mortality and hospitalization in the elderly. However, data are scarce about their response to device treatment such as cardiac resynchronization therapy (CRT). We aimed to evaluate the age-related differences in the effectiveness of CRT, procedure-related complications, and long-term outcome. Between 2000 and 2020, 2656 patients undergoing CRT implantation were registered and analyzed retrospectively. Patients were divided into 3 groups according to their age: group I, 75 years. The primary endpoint was the echocardiographic response defined as a relative increase > 15% in left ventricular ejection fraction (LVEF) within 6 months, and the secondary endpoint was the composite of all-cause mortality, heart transplantation, or left ventricular assist device implantation. Procedure-related complications were also assessed. After implantation, LVEF showed significant improvement both in the total cohort [28% (IQR 24/33) vs. 35% (IQR 28/40); p p p p p = 0.41). During the follow-up, 1574 (59%) patients died. Kaplan–Meier curves revealed a significantly lower survival rate in the older groups (log-rank p p = 0.15). Our results demonstrate that CRT is as effective and safe therapy in the elderly as for young ones. The present data suggest that patients with appropriate indications benefit from CRT in the long term, regardless of age.
Databáze: OpenAIRE
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