The effects of interleukin-2 treatment on endothelin and the activation of the hypothalamic-pituitary-adrenal axis
| Autor: | Eckhart Weidmann, Claudia Raab, Thomas Haak, Klaus Badenhoop, Klaus Henning Usadel, Lothar Bergmann, Alexander Schmidt |
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| Rok vydání: | 1999 |
| Předmět: |
endocrine system
medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Radioimmunoassay Adrenocorticotropic hormone Peptide hormone Biology Basal (phylogenetics) Endocrinology Cytokine medicine.anatomical_structure Internal medicine medicine Endothelin receptor hormones hormone substitutes and hormone antagonists Hypothalamic–pituitary–adrenal axis Hormone |
| Zdroj: | Clinical Endocrinology. 50:37-44 |
| ISSN: | 0300-0664 |
| DOI: | 10.1046/j.1365-2265.1999.00592.x |
| Popis: | OBJECTIVE Recent reports suggest that complex interactions exist between the neuroendocrine and immune systems. It has been shown for example that cytokines are able to stimulate the hypothalamo-pituitary-adrenal axis. In addition, some studies present evidence that endothelin is able to modulate the activity of several hypothalamic-pituitary axes, e.g. by inducing the ACTH production. DESIGN We investigated the effects of interleukin-2 on endothelin levels and the hypothalamo-pituitary-adrenal axis. We determined the interleukin-6, big-endothelin, endothelin-1, ACTH, cortisol and AVP responses to intravenously and subcutaneously administered interleukin-2 in 8 cancer patients in a randomized placebo controlled trial. PATIENTS 8 Patients (2 female and 6 male), age 44 ± 4.8 years, were enrolled. All patients had a World Health Organization performance status of 1 or less and a Karnofsky Index of at least 80%. MEASURMENTS Blood-samples were taken before and 15, 30, 45, 60, 120, 180, 240, 300 and 360 min after interleukin-2 injection. Cytokine serum levels and the plasma levels of big-endothelin, endothelin, ACTH and AVP were analysed using radioimmunoassays. Cortisol was assayed by an enzyme-linked immunosorbent assay. RESULTS Interleukin-2 treatment significantly increased plasma big-endothelin levels (P |
| Databáze: | OpenAIRE |
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