Loss of alkaline ceramidase inhibits autophagy in Arabidopsis and plays an important role during environmental stress response
| Autor: | Sunil Kumar Sahu, Ping Zheng, Hong-Yun Zeng, Jian-Xin Wu, Liqun Huang, Nan Yao, Zhe Liu, Shi Xiao |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Ceramide biology Physiology Chemistry Autophagy Cellular homeostasis Plant Science biology.organism_classification Alkaline Ceramidase Sphingolipid Cell biology 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology Arabidopsis Arabidopsis thaliana lipids (amino acids peptides and proteins) Signal transduction |
| Zdroj: | Plant, Cell & Environment. 41:837-849 |
| ISSN: | 0140-7791 |
| DOI: | 10.1111/pce.13148 |
| Popis: | Sphingolipids, a class of bioactive lipids found in cell membranes, can modulate the biophysical properties of the membranes and play a critical role in signal transduction. Sphingolipids are involved in autophagy in humans and yeast, but their role in autophagy in plants is not well understood. In this study, we reported that the AtACER, an alkaline ceramidase that hydrolyses ceramide to long-chain base (LCB), functions in autophagy process in Arabidopsis. Our empirical data showed that the loss of AtACER inhibited autophagy, and its overexpression promoted autophagy under nutrient, salinity, and oxidative stresses. Interestingly, nitrogen deprivation significantly affected the sphingolipid's profile in Arabidopsis thaliana, especially the LCBs. Furthermore, the exogenous application of LCBs also induced autophagy. Our findings revealed a novel function of AtACER, where it was found to involve in the autophagy process, thus, playing a crucial role in the maintenance of a dynamic loop between sphingolipids and autophagy for cellular homeostasis under various environmental stresses. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text