Fate of thickened perineurial cell basement membrane in a diabetic patient following pancreas transplantation
| Autor: | Peter C. Johnson, C. P. Jones, J. L. Beggs, J. H. Targovnik, A. G. Olafsen, C. J. Watkins |
|---|---|
| Rok vydání: | 1988 |
| Předmět: | |
| Zdroj: | Proceedings, annual meeting, Electron Microscopy Society of America. 46:344-345 |
| ISSN: | 2690-1315 0424-8201 |
| Popis: | The perineurial sheath of dermal nerves is usually composed of one to several cell layers. Thickening of perineurial cell basement membranes (PCBM) is a common feature in diabetics. Since PCBM thickening may have relevance to the cause of diabetic neuropathy the fate of thickened PCBM following various treatment regimens is of prime importance. In this study, we examined dermal nerves of monozygotic twins discordant for diabetes to determine the effects of pancreas transplantation on PCBM thickness.Patient History and Methods: This 53 year old diabetic man with an 18 year history of insulin dependency presented with progressive development of retinopathy, nephropathy and neuropathy. Pancreas transplantation (donor Identical twin) was performed to treat diabetic complications. Shortly after transplantation, the patient became normoglycemic and has remained euglycemic for 2 years. Signs and symptoms of diabetic complications improved; nerve conductance in the lower extremities improved. Abdominal skin biopsies were taken from the twins before transplantation and subsequent biopsies (1,2 yr post-transplant) were taken from the diabetic patient. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|