| Autor: |
R.L. Rodgers, Ying Sun, Li Wu, Jiang Wu |
| Rok vydání: |
2004 |
| Předmět: |
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| Zdroj: |
IEEE 30th Annual Northeast Bioengineering Conference, 2004. Proceedings of the. |
| DOI: |
10.1109/nebc.2004.1299998 |
| Popis: |
In this study, a parameter estimation method has been developed for models of biomedical pathways. The inconsistency among experimental data that may come from different sources is reduced. The resulting parameters define a well-behaved mathematical model in the steady state. Based on experimental data collected separately from individual sub steps of a pathway, this approach achieves overall optimization in two steps: flux optimization and individual parameter optimization. The method is useful for identifying an initial state in modeling the dynamics of a biochemical pathway. The method has been effective as applied to a model of glycolysis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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