OVA-Induced Allergic Airway Inflammation Mouse Model
| Autor: | Vanessa R. Souza, Caroline M. Ferreira, Fernando A. Oliveira, Mateus B. Casaro |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Allergy biology Allergic airway inflammation business.industry Mucus production Airway inflammation respiratory system medicine.disease respiratory tract diseases 03 medical and health sciences Ovalbumin 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure 030228 respiratory system Eosinophilic Immunology biology.protein Medicine business Sensitization Asthma |
| Zdroj: | Methods in Molecular Biology ISBN: 9781493989935 |
| DOI: | 10.1007/978-1-4939-8994-2_28 |
| Popis: | Asthma is a worldwide public health issue, affecting the sufferer's quality of life. Many researchers are extensively studying the cellular processes involved in the affected airways. Experimental asthma using animals has been performed for a long time, mainly applying murine models due to well-known advantages. The aim of this study is to present an allergic airway inflammation protocol in mice. Basically, the allergic airway inflammation is induced by intraperitoneal sensitization and intratracheal challenge with ovalbumin (OVA). The model provided here mimics acute asthma characteristics including excessive mucus production, airway hyperresponsiveness, and eosinophilic airway inflammation. |
| Databáze: | OpenAIRE |
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