A Facile Oxidation of Tertiary Amines to Lactams by Using Sodium Chlorite: Process Improvement by Precise pH Adjustment with CO2
| Autor: | Changhu Chu, Chaoyang Liu, Haozhou Sun, Cheng Qin, Tiannuo Yang, Wenxian Zhang, Yuan Zhou, Yani Li, Zheng Robert Jia |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Synlett. 33:993-997 |
| ISSN: | 1437-2096 0936-5214 |
| DOI: | 10.1055/s-0040-1719920 |
| Popis: | By using cheap and innocuous sodium chlorite, a series of tertiary amines have been oxidized to the corresponding lactams with good selectivity and high yield. In this method, neither transition-metal catalyst nor oxidant was used. In the oxidation step, the pH of the sodium chlorite was precisely adjusted to pH around 6 using CO2, such pH is a compromise between oxidative properties, chemical stability, and unwanted precipitation. In addition, buffer salts are not necessary, which allows this oxidation reaction to be performed under safe and environmentally benign conditions. |
| Databáze: | OpenAIRE |
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