A Trimethylsilylamine-Acyl Fluoride Amide Bond Forming Protocol for Weakly Nucleophilic Amines that is Amenable to the Parallel Synthesis of Di(hetero)arylamides

Autor:	David S. Grierson, Maryam Zamiri
Rok vydání:	2016
Předmět:	010405 organic chemistry Organic Chemistry 010402 general chemistry 01 natural sciences Combinatorial chemistry Catalysis 0104 chemical sciences chemistry.chemical_compound chemistry Nucleophile Peptide bond Organic chemistry Acetonitrile Fluoride
Zdroj:	Synthesis. 49:571-578
ISSN:	1437-210X 0039-7881
Popis:	The reaction of a 2-pyridinone-based acid fluoride with the N–TMS derivatives of different weakly nucleophilic heteroaryl/arylamines in acetonitrile containing catalytic fluoride ion provides a clean, efficient and simple means to access a diverse range of polar di(hetero)arylamide structures. This amide bond forming protocol is readily amenable to the parallel synthesis of compound libraries.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8042afb4aab297b18a186ada6e269743 https://doi.org/10.1055/s-0036-1588603 Zobrazit plný text záznamu