Synthesis of the cardiotonic bemarinone, 5,6-dimethoxy-4-methyl-2(1H)-quinazolinone, utilizing a directed metalation approach

Autor:	Stephen M. Stefanick, Margaret M. Lam, Seymour D. Levine, Sergio Cesco-Cancian, Charles Francis Kasulanis, Conley Richard A, Arthur C. Fabian, Barton Donald L, Stephen Currey, Gregory C. Lindabery
Rok vydání:	1995
Předmět:	chemistry.chemical_compound chemistry Metalation Organic Chemistry Electrophile Bemarinone Combinatorial chemistry Quinazolinone
Zdroj:	Journal of Heterocyclic Chemistry. 32:761-770
ISSN:	1943-5193 0022-152X
Popis:	Several methods for the synthesis of bemarinone, 5,6-dimethoxy-4-methyl-2(1H)-quinazolinone, were explored with the most successful being a directed metalation route. Details of the lithiation and the subsequent reaction with electrophiles of 3′,4′-dimethoxy-2,2-dimethylpropioanilide and other derivatives of 3,4-dimethoxyaniline are given.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::80420d7ea61a1fdc3b65b175c19375a6 https://doi.org/10.1002/jhet.5570320312 Zobrazit plný text záznamu Plný text