Methylene blue photodynamic therapy to sterilize deep tissue abscess cavities: a phase 1 trial in progress and simulation study

Autor:	Lam Nguyen, Timothy M. Baran, Thomas H. Foster, Ashwani K. Sharma
Rok vydání:	2021
Předmět:	medicine.medical_specialty Percutaneous business.industry medicine.medical_treatment Phases of clinical research Photodynamic therapy medicine.disease chemistry.chemical_compound chemistry In vivo Deep tissue medicine Radiology Abscess business Adverse effect Methylene blue
Zdroj:	Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2021.
Popis:	Despite advances in image-guided percutaneous drainage, deep tissue abscesses remain a serious cause of morbidity, mortality, and hospital stay. We initiated a Phase 1 clinical trial exploring safety and feasibility of methylene blue (MB) photodynamic therapy during drainage. Five subjects have been treated, with no study-related adverse events and high technical success. Monte Carlo simulations were used to examine effects of optical properties on delivered light dose. We found that light dose is highly dependent upon MB uptake and Intralipid concentration. These results motivated construction of an optical spectroscopy system for determination of abscess wall optical properties in vivo.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8040cf882467c2024a1fadb154538871 https://doi.org/10.1117/12.2575949 Zobrazit plný text záznamu