Non-eosinophilic COPD is associated with severe emphysema assessed by quantitative computed tomography
| Autor: | Hsiao-Yun Kuo, Shu-Chuan Ho, Kang-Yun Lee, Kuan-Yuan Chen |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
COPD medicine.diagnostic_test business.industry Significant difference respiratory system medicine.disease Gastroenterology respiratory tract diseases Internal medicine Hounsfield scale Eosinophilic medicine Longitudinal cohort Quantitative computed tomography business Pathological Lung field |
| Zdroj: | Allergy and immunology. |
| DOI: | 10.1183/13993003.congress-2020.198 |
| Popis: | Background: Emphysema is a key pathological process observed in COPD and has been considered to be resulted from chronic airway inflammation which non-eosinophil cells (i.e. neutrophils, macrophages and CD8+ lymphocytes) are predominantly involved Objectives: To compare the severity of emphysema between eosinophilic and non-eosinophilic COPD patients Methods: We analyzed 100 COPD patients from longitudinal cohort study performed since Jan 2017 in Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan. All recruited patients were divided into eosinophilic and non-eosinophilic groups with cut-offs for blood eosinophils ≧4% or ≧300 cells/μL.The severity of emphysema in both groups were assessed by quantitative computed tomography (CT) using density mask method with a threshold of ≦–950 Hounsfield units (HU) and represented with persentage of low attenuation area (LAA%). The severe emphysema was defined as ≧30% LAA of total lung field Results: Among enrolled subjects in the study, the propotion of non-eosinophilic COPD was 76%. The comparison of emphysema (%LAA) between eosinophilic and non-eosinophilic groups in total and individual lobe of lung field was no significant difference. However, the ratio of severe emphysema (≧30% LAA ) in total lung field was significant higher in non-eosinophilic than eosinophilic groups of COPD patients(37% vs 0%, p Conclusions: In our study, we presented the ratio of severe emphysema was higher in non-eosinophilc COPD patients and associated longitudinal change of clinical parameters would keep ongoing study |
| Databáze: | OpenAIRE |
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