High antibacterial activity and low toxicity of pyridoxal derivatives of chitosan and their nanoparticles

Autor:	Andreii S. Kritchenkov, Elizaveta S. Mitrofanova, Alexander G. Tskhovrebov, Anton R. Egorov, Anastasia A. Godzishevskaya, Margarita N. Kurasova, Victor N. Khrustalev, Niyaz Z. Yagafarov, Alexey A. Artemjev, Elena V. Andrusenko, Moises J. Ballesteros Meza
Rok vydání:	2021
Předmět:	Low toxicity Ionic bonding Nanoparticle General Chemistry In vitro Chitosan chemistry.chemical_compound chemistry medicine Gentamicin Antibacterial activity Pyridoxal medicine.drug Nuclear chemistry
Zdroj:	Mendeleev Communications. 31:504-506
ISSN:	0959-9436
Popis:	The pyridoxal derivatives of chitosan with various degrees of substitution (DS) were synthesized from low-, moderate- and high-molecular-weight chitosans by their reaction with pyridoxal followed by treatment with NaBH4. The derivative of moderate molecular weight and high DS demonstrated a maximum antibacterial activity against S. aureus and E. coli. The nanoparticles of this derivative obtained by ionic gelation are nontoxic, and they exhibit a high in vitro antibacterial effect, which slightly exceeds that of ampicillin and gentamicin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::803cbf1604bc67c7ef34f4d033cde652 https://doi.org/10.1016/j.mencom.2021.07.022 Zobrazit plný text záznamu Full Text from ScienceDirect