Volatile organic compounds generated by cultures of bacteria and viruses associated with respiratory infections
| Autor: | Natali Svobodin, Amir Abd El Qader, Yonat Shemer Avni, Orli Sagi, David Lieberman, Yehuda Zeiri, Tsilia Lazarovitch |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Pharmacology
Mycoplasma pneumoniae Microbiological culture Chromatography biology Chemistry Clinical Biochemistry General Medicine medicine.disease_cause biology.organism_classification Biochemistry Legionella pneumophila Virus Analytical Chemistry Haemophilus influenzae Moraxella catarrhalis Drug Discovery medicine Molecular Biology Pathogen Bacteria |
| Zdroj: | Biomedical Chromatography. 29:1783-1790 |
| ISSN: | 0269-3879 |
| DOI: | 10.1002/bmc.3494 |
| Popis: | Respiratory infections (RI) can be viral or bacterial in origin. In either case, the invasion of the pathogen results in production and release of various volatile organic compounds (VOCs). The present study examines the VOCs released from cultures of five viruses (influenza A, influenza B, adenovirus, respiratory syncitial virus and parainfluenza 1 virus), three bacteria (Moraxella catarrhalis, Haemophilus influenzae and Legionella pneumophila) and Mycoplasma pneumoniae isolated colonies. Our results demonstrate the involvement of inflammation-induced VOCs. Two significant VOCs were identified as associated with infectious bacterial activity, heptane and methylcyclohexane. These two VOCs have been linked in previous studies to oxidative stress effects. In order to distinguish between bacterial and viral positive cultures, we performed principal component analysis including peak identity (retention time) and VOC concentration (i.e. area under the peak) revealing 1-hexanol and 1-heptadecene to be good predictors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text