| Autor: |
Mohd A. Alam, Abdulelah I. Al-Suwaydani, Mohammed Raish, Yousef A. Bin Jardan, Abdul Ahad, Fahad I. Al-Jenoobi |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Current Drug Metabolism. 23:842-849 |
| ISSN: |
1389-2002 |
| DOI: |
10.2174/1389200223666220623155939 |
| Popis: |
Background: Numerous herbs are reported to have anti-hyperglycemic activity and are frequently used in combination with prescription drugs to lower the blood glucose levels in diabetic patients, without proper knowledge about the possibility of herb-drug interaction. Objectives: To investigate the effect of cumin and garden cress on pharmacokinetics (PK) and pharmacodynamics (PD) of gliclazide (GLZ) in nicotinamide-streptozotocin diabetic model. Methods: Diabetic animals of groups II-IV were treated with GLZ, cumin, ‘cumin + GLZ’, garden cress and ‘garden cress + GLZ’. Herb’s treatments were given for two weeks, and GLZ was administered in a single dose. Blood glucose levels (BGLs) were measured at pre-determined time points. Plasma samples of pharmacokinetic study were analyzed using UPLC-MS/MS. GLZ fragment at m/z 324.1>127 was monitored. Results: Cumin and garden cress have shown 15.3% and 15.9% reduction in mean BGL (1-24h) (p-value < 0.001), respectively. GLZ reduced mean BGL by 30.0%, which was significantly better than cumin and garden cress (pvalue Conclusion: PK/PD-based herb-drug interaction was observed. Concurrently administered garden cress + GLZ showed improved antidiabetic effect and has enhanced GLZ bioavailability. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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