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Objectives: This study investigates whether there is a credible link between Vitamin D concentration in the human blood and COVID-19 infection, severity, and death in the general population. Design: The study adopts a meta-analytical approach to synthesize available secondary information. Emphasis is given to works published within the COVID-19 duration. The study draws articles from scholarly medical sites to provide credit to the analysis and results. Setting: The study is set on a global stage because the articles are drawn from different parts of the world. Mainly, the changing nature of the virus and the continuing revelation of its operations under various conditions arouse interest among scholars that share investigation procedures. Selection, Entry, Exclusion Criteria Interventions: The articles used in the investigation are those from peer reviews. Mainly, articles with a document identifier number (DOI) qualified for the analysis. At the same time, the study focused on articles exploring the relationship between COVID-19 and Vitamin D only. Primary and Secondary Outcome Measures: The primary outcome is that Vitamin D improves the body's immune response and suppresses viral activity. The secondary effect is that Vitamin D deficiency, coupled with other comorbidities, increases the risk of death and severe coronavirus infection. Results: Results confirm a strong relationship between 25(OH)D concentration and the body's ability to fight the COVID-19 infection. Individuals with low Vitamin D concentrations of less than 20 ng/ml experienced severe symptoms. Findings indicate that Vitamin D3 supplements increase 25(OH)D levels, making the body withstanding the virus. Conclusion: Thus, Vitamin D concentration in the blood directly correlates with COVID-19 severity and mortality. Keywords: COVID-19, Vitamin D, Immune System, SARS, ARDS |
