An Efficient Synthetic Route to Novel 3-Alkyl- and 3-Aryl-4-iodophenols

Autor:	Lucía Díaz, Marta Corrales, Hermann Gesine Johanna, Robert Alan Goodnow, Peter D. Edwards, Michael C. Annis
Rok vydání:	2008
Předmět:	chemistry.chemical_classification chemistry.chemical_compound chemistry Suzuki reaction Aryl Organic Chemistry Halogenation Combinatorial chemistry Catalysis Alkyl Isopropyl
Zdroj:	Synthesis. 2008:221-224
ISSN:	1437-210X 0039-7881
Popis:	An efficient method for the preparation of novel 3-alkyl- and 3-aryl-4-iodophenols from 3-alkyl- and 3-arylphenols is de- scribed. As part of an ongoing project it was necessary to access a series of novel 4-arylphenols containing sterically de- manding functionality at the 3-position; in particular phe- nols with isopropyl, tert-butyl, and phenyl groups were of interest for our work. A viable approach to these com- pounds via palladium-catalysed coupling of the 3-alkyl- and 3-aryl-4-halophenols 1 (Figure 1) was proposed. However, literature searches revealed a paucity of infor- mation regarding the synthesis of these 4-halogenated 3- alkyl- and 3-arylphenols.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::801c2b64cb3629b3c6823e90855ff52e https://doi.org/10.1055/s-2007-1000860 Zobrazit plný text záznamu