Risk factors for small bowel bleeding in chronic nonsteroidal anti-inflammatory drug users

Autor:	Ban-Suk Kim, Chung-Hwan Jun, Kyu-Man Cho, Park Changhwan, Hyun-Chul Kim, Tae-Jong Kim, Sung-Kyu Choi, Seon-Young Park, Jong-Sun Rew, Dong-Jun Son, Jin Ook Chung
Rok vydání:	2015
Předmět:	medicine.medical_specialty Thienopyridine business.industry Incidence (epidemiology) Medical record Gastroenterology Odds ratio medicine.disease Confidence interval Surgery Coronary artery disease Internal medicine medicine Rebamipide Enteropathy business medicine.drug
Zdroj:	Journal of Digestive Diseases. 16:499-504
ISSN:	1751-2972
DOI:	10.1111/1751-2980.12269
Popis:	Objective The incidence of nonsteroidal anti-inflammatory drugs (NSAIDs)-induced enteropathy is currently increasing. However, the predictors of small bowel bleeding (SBB) associated with NSAIDs are unknown. This study aimed to assess the risk factors of SBB in chronic NSAIDs users. Methods We retrospectively compared the medical records of 147 patients receiving NSAIDs in a tertiary-care setting (31 with SBB and 116 without previous bleeding events) and analyzed the predictors of SBB. Results In total, 31 patients underwent video capsule endoscopy to detect SBB, 74.2% of whom showed the evidence of SBB. Non-invasive treatment was performed in 90.3% of the patients. Multivariate logistic regression analysis revealed that the presence of coronary artery disease [adjusted odds ratio (aOR) 12.43, 95% confidence interval (CI) 1.19–130.34, P = 0.04], use of thienopyridine (aOR 16.93, 95% CI 3.78–75.72, P
Databáze:	OpenAIRE
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