Tandem Prins Strategy for the Synthesis of Spiropyrrolidine and Spiropiperidine Derivatives

Autor:	Dayaka Satyanarayana, Bharatam Jagadeesh, B. Sridhar, M. Rajashekhar Reddy, Basi V. Subba Reddy, C. Ravikumar Reddy, Suresh Yarlagadda
Rok vydání:	2015
Předmět:	Cascade reaction Tandem Derivative (finance) Cascade Chemistry Organic Chemistry Organic chemistry Physical and Theoretical Chemistry
Zdroj:	European Journal of Organic Chemistry. 2015:3076-3085
ISSN:	1434-193X
DOI:	10.1002/ejoc.201500215
Popis:	Cascade cyclization of a 3-[(3-methylbut-2-enylamino)methyl]but-3-en-1-ol derivative with aldehydes in the presence of TMSOTf at 0 °C under mild conditions provides the corresponding spiropyrrolidine scaffolds in good yields. Similar cyclization of a 3-[(4-methylpent-3-enylamino)methyl]but-3-en-1-ol derivative with aldehydes affords the correponding spiropiperidine compounds. This is a new approach for the construction of biologically relevant spirocycles in a single-step process.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::800d25d6680ef29596adc1789987bf77 https://doi.org/10.1002/ejoc.201500215 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.