Population dynamics of arterial smooth muscle cells
| Autor: | S.C. Nam, Wilbur A. Thomas, R.A. Florentin, Kyu Taik Lee, J.M. Reiner, K. Janakidevi |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Aqueous extract
education.field_of_study Pathology medicine.medical_specialty Intimal hyperplasia medicine.medical_treatment Clinical Biochemistry Population Anatomy Biology medicine.disease Proliferative response Pathology and Forensic Medicine Aortic tissue medicine education Molecular Biology Mitosis Saline Arterial smooth muscle cells |
| Zdroj: | Experimental and Molecular Pathology. 21:259-267 |
| ISSN: | 0014-4800 |
| Popis: | Previously we demonstrated in swine that a single ip injection of an aqueous extract of swine aortic tissue (containing less than a mg of protein) would inhibit entry of arterial smooth muscle cells into mitosis for at least 2 hr. In the current study we investigated the effect of repeated injections of aortic extract for periods up to 104 days on the development of intimal hyperplasia resulting from a combination of hypercholesterolemia and trauma producd by an intraarterial balloon. Quantitatively both the extent and the thickness of intimal lesions were found to be significantly less in aortic extract treated swine than in paired controls given only saline. Qualitative features did not appear to differ and no general or local toxic effects were observed. |
| Databáze: | OpenAIRE |
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