Potential diagnostic and therapeutic agents for malignant melanoma: Synthesis of heavy radiohalogenated derivatives of methylene blue by electrophilic and nucleophilic methods
Autor: | R. N. Carpenter, Eva M. Link, Joseph S. Mitchell, Ian Brown |
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Rok vydání: | 1986 |
Předmět: |
chemistry.chemical_classification
Chemistry Health Toxicology and Mutagenesis 18-Crown-6 Public Health Environmental and Occupational Health Ether Pollution Analytical Chemistry Electrophilic substitution chemistry.chemical_compound Nuclear Energy and Engineering Nucleophile Electrophile Nucleophilic substitution Organic chemistry Radiology Nuclear Medicine and imaging Spectroscopy Methylene blue Crown ether |
Zdroj: | Journal of Radioanalytical and Nuclear Chemistry Letters. 107:337-351 |
ISSN: | 1588-2780 0236-5731 |
DOI: | 10.1007/bf02164199 |
Popis: | Heavy radiohalogenated derivatives of methylene blue of potential value as possible diagnostic and endoradiotherapeutic agents for malignant melanoma, have been synthesized by both electrophilic and nucleophilic reaction routes. Thermal halogen isotope exchange in molten crown ether catalyst facilitated the rapid preparation of high specific activity radioiodinated and [211At]-astatinated derivatives; radiochemical yields were in the order of 60–79%. Radiohalogenation mediated by chloramine-T or via diazonium intermediary proved more laborious, far less efficient and inappropriately is only suited to the preparation of low specific activity product. |
Databáze: | OpenAIRE |
Externí odkaz: |
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