ChemInform Abstract: Orthogonal N,N-Deprotection Strategies of β-Amino Esters

Autor:	Massimo Gianotti, Andrew D. Smith, Stephen G. Davies, Peter M. Kelly, Steven D. Bull
Rok vydání:	2010
Předmět:	Reaction conditions chemistry Amino esters chemistry.chemical_element Organic chemistry Stereoselectivity Lithium General Medicine Oxidative phosphorylation Conjugate
Zdroj:	ChemInform. 33
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200214209
Popis:	β-Amino esters derived from the stereoselective conjugate addition of homochiral lithium N-benzyl-N-α-methyl-4-methoxybenzylamide to α,β-unsaturated esters may be orthogonally mono-N-deprotected under either oxidative or acid-promoted reaction conditions. Further oxidative deprotection affords β-amino acids or β-lactams.
Databáze:	OpenAIRE
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