MPDB: a unified multi-domain protein structure database integrating structural analogue detection

Autor: Chun-Xiang Peng, Xiao-Gen Zhou, Yu-Hao Xia, Yang Zhang, Gui-Jun Zhang
Rok vydání: 2021
DOI: 10.1101/2021.10.27.466092
Popis: With the development of protein structure prediction methods and biological experimental determination techniques, the structure of single-domain proteins can be relatively easier to be modeled or experimentally solved. However, more than 80% of eukaryotic proteins and 67% of prokaryotic proteins contain multiple domains. Constructing a unified multi-domain protein structure database will promote the research of multi-domain proteins, especially in the modeling of multi-domain protein structures. In this work, we develop a unified multi-domain protein structure database (MPDB). Based on MPDB, we also develop a server with two functional modules: (1) the culling module, which filters the whole MPDB according to input criteria; (2) the detection module, which identifies structural analogues of the full-chain according to the structural similarity between input domain models and the protein in MPDB. The module can discover the potential analogue structures, which will contribute to high-quality multi-domain protein structure modeling.
Databáze: OpenAIRE