Ten-year follow-up of subjects who received bronchial thermoplasty (BT) in 3 randomized controlled studies (BT10+)
| Autor: | Michael Simoff, Michel Laviolette, Charlene McEvoy, Jussara Fiterman, Rekha Chaudhuri, Richard G. Barbers, Adalberto Sperb Rubin, José Roberto Lapa e Silva, Salman Siddiqui, Robert Niven, Pallav L. Shah, Frances Nolan, Sumita Khatri, Ronald Olivenstein, David Duhamel, Karin Klooster, Kaharu Sumino |
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| Rok vydání: | 2019 |
| Předmět: |
Spirometry
medicine.medical_specialty Bronchial thermoplasty medicine.diagnostic_test Demographics business.industry Controlled studies Uncontrolled asthma 03 medical and health sciences 0302 clinical medicine 030228 respiratory system Quality of life Internal medicine Medicine 030212 general & internal medicine business Endoscopic treatment Lung function |
| Zdroj: | Airway pharmacology and treatment. |
| DOI: | 10.1183/13993003.congress-2019.rct3782 |
| Popis: | Background: BT is an endoscopic treatment for uncontrolled asthma. The long-term efficacy and safety of BT beyond 5 years is not known. Objective: To evaluate the efficacy and safety of BT at 10+ years follow-up. Methods: BT10+ is an international, multi-center, ≥10yrs follow-up study on subjects who were previously enrolled in the AIR, RISA and AIR2 trials. Demographics, quality of life, lung function, severe exacerbations (SE, defined as exacerbations requiring systemic corticosteroids) and healthcare utilisation for the previous year were collected. Results: Of the 429 subjects enrolled in the previous studies, 192 subjects had a follow-up at 10.6-15.8 years (12.1 median) post-treatment at 16 centers: 137 treated with BT during a previous study, 18 control/sham treated with BT post-study, and 37 control/sham only. Rates for hospitalisations, emergency visits and SE for BT subjects from the year prior to BT to the year prior to the BT 10+ visit are shown in Figure 1. No increases in hospitalisations or ER visits were observed compared to baseline and SE were stable compared to Year 1. No deterioration in rates were shown for control/sham only and post-study BT patients. Quality of life and spirometry results were comparable between Years 1, 5, and 10+ for all groups. Conclusion: The BT10+ study suggests that efficacy of bronchial thermoplasty is sustained over 10 years. Funding: Boston Scientific |
| Databáze: | OpenAIRE |
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