Two-color fluorescence monitoring in PDT treatment

Autor:	Mikhail Yu. Kirillin, A. V. Khilov, D. A. Loginova, S.V. Gamayunov, Ilya V. Turchin
Rok vydání:	2018
Předmět:	Fluorescence-lifetime imaging microscopy Materials science medicine.medical_treatment Monte Carlo method medicine Photodynamic therapy Photosensitizer Penetration depth Photobleaching Fluorescence Imaging phantom Biomedical engineering
Zdroj:	2018 International Conference Laser Optics (ICLO).
DOI:	10.1109/lo.2018.8435404
Popis:	The fluorescence imaging device for localizing a tumor in a patient's body and monitoring photobleaching of a photosensitizer (PS) in course of photodynamic therapy was constructed. The system includes two LED sources at 405 and 660 nm for excitation of chlorine-based PSs. The ratio of fluorescence signals upon excitation at these wavelengths was demonstrated to provide evaluation of PS penetration depth in biotissues after topical administration. The study included Monte Carlo simulations that are in a good agreement with phantom experiment.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7fe6fcf064955b4e3d991ddd9e10bccc https://doi.org/10.1109/lo.2018.8435404 Zobrazit plný text záznamu