| Popis: |
Before the discovery of the histamine H2-receptor antagonists the classical anticholinergics were the only inhibitors of gastric acid secretion available. Their clinical use, however, was limited by unwanted effects and the results of treatment disappointing. This picture changed completely in the seventies with the advent of the histamine H2-receptor antagonist, cimetidine. An overwhelming number of studies showed that suppression of gastric acid secretion is indeed the mainstay in the treatment of acid peptic diseases. However safe these compounds proved to be, H2-receptors are not limited to the parietal cell and neither are the effects of the antagonists. Anticholinergics and histamine H2-receptor antagonists act systemically by blocking their specific receptors throughout the body. |
