21. Effect of Hydralazine on Spontaneous Activity of Portal Veins from Spontaneously Hypertensive Rats
| Autor: | T. M. Glenn, S. Greenberg, K. Gaines |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Vascular smooth muscle biology business.industry Thromboxane Tranylcypromine Portal vein Hydralazine Thromboxane B2 chemistry.chemical_compound Endocrinology chemistry Internal medicine cardiovascular system biology.protein Medicine Cyclooxygenase business Inhibitory effect medicine.drug |
| DOI: | 10.1159/000430644 |
| Popis: | The effect of acute hydralazine administration, in vitro on vascular smooth muscle tone, was evaluated in the portal veins obtained from Wistar-Kyoto normotensive (WKY) and spontaneously hypertensive rats (SHR). Hydralazine (1 s 10-8M to 10-4M) produced, concentration-related decreases in the spontaneous tone of portal vein obtained from SHR and WKY. Hydralazine was a more effective inhibitor of tone in portal vein obtained from WKY when compared with SHR. Portal vein obtained from SHR released more thromboxane B2 than portal vein obtained from WKY. The inhibitory effect of hydralazine on spontaneous tone in portal vein obtained from SHR and WKY was diminished in portal vein incubated with imidazole, an inhibitor of thromboxane synthetase or eicosatetraynoic acid, an inhibitor of prostaglandin cyclooxygenase. However, tranylcypromine, an inhibitor of prostacyclin synthetase did not affect the vesodilator activity of hydralazine. These findings suggest that hydralazine may inhibit vascular smooth muscle tone by inhibiting thromboxane synthesis within the vascular smooth muscle. |
| Databáze: | OpenAIRE |
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