Systematic review of the use of topical diltiazem compared with glyceryltrinitrate for the nonoperative management of chronic anal fissure

Autor:	Mirza K. Baig, Pauline A Whitehouse, P. Sains, M. S. Sajid
Rok vydání:	2012
Předmět:	medicine.medical_specialty business.industry First line Gastroenterology Chronic anal fissure law.invention Clinical trial Randomized controlled trial law Relative risk Meta-analysis Anesthesia Internal medicine Medicine Diltiazem Nonoperative management business medicine.drug
Zdroj:	Colorectal Disease. 15:19-26
ISSN:	1462-8910
DOI:	10.1111/j.1463-1318.2012.03042.x
Popis:	Aim The study analyzed clinical trials investigating the effectiveness of diltiazem (DTZ) and glyceryltrinitrate (GTN) for the nonsurgical management of chronic anal fissure (CAF). Method Randomized trials on the effectiveness of DTZ and GTN were analyzed systematically using RevMan® where combined outcome was expressed as risk ratio (RR). Results Seven randomized controlled trials that included 481 patients were analyzed. Two-hundred and thirty-eight patients were treated with DTZ and 243 patients were treated with GTN. There was significant heterogeneity [Tau2 = 0.24, χ2 = 13.16, d.f. = 6 (P
Databáze:	OpenAIRE
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