A Case of a Pregnant Woman Diagnosed as HavingALK-rearranged Lung Adenocarcinoma
| Autor: | Shigeki Tomita, Kazuhisa Takahashi, Shigehiro Yagishita, Keiko Muraki, Osamu Nagashima, Naoko Arano, Kota Nakamura, Tomohito Takeshige, Moegi Komura, Shinichi Sasaki, Hiroshi Izumi |
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| Rok vydání: | 2018 |
| Předmět: |
Pharmacology
Alectinib Cancer Research Pathology medicine.medical_specialty Lung business.industry Cancer medicine.disease General Biochemistry Genetics and Molecular Biology medicine.anatomical_structure Medicine Anaplastic lymphoma kinase Adenocarcinoma Sputum medicine.symptom business Lung cancer Brain metastasis |
| Zdroj: | In Vivo. 32:1205-1209 |
| ISSN: | 1791-7549 0258-851X |
| Popis: | A 28-year-old woman who was 34 weeks pregnant was admitted with complaints of cough and blood-stained sputum. After delivery of the baby at 37 weeks gestation, computed tomography and magnetic resonance imaging revealed a tumor in the right lung and a 15-mm brain metastasis. A diagnosis of lung adenocarcinoma was made, cT4N3M1b (stage IV disease) by pleural fluid cytology. Additional testing for anaplastic lymphoma kinase (ALK) fusion protein showed a strongly positive result, which was then confirmed by fluorescence in situ hybridization. The patient was started on treatment with alectinib, and the tumor and brain metastasis had almost vanished by 2 months after the start of this treatment. In the literature, there are 59 reports of lung cancer diagnosed during pregnancy, including two cases of cancer with expression of ALK fusion protein and five cases showing epidermal growth factor receptor mutation. The type of mutation should be taken into consideration while selecting for the appropriate therapeutic strategy. |
| Databáze: | OpenAIRE |
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