DYNAMICS OF THE TISSUE SYSTEM OF PLASMINOGEN REGULATORS IN CUTANEOUS MELANOMA WITH CHRONIC PAIN IN FEMALE MICE
| Autor: | V. A. Bandovkina, Natalia D. Cheryarina, Irina V. Kaplieva, I. M. Kotieva, L S Kozlova, L. Ya. Rozenko, Oleg I. Kit, Elena M. Frantsiyants, Yu. A Pogorelova, Lidia K. Trepitaki |
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| Rok vydání: | 2018 |
| Předmět: |
Urokinase
business.industry Melanoma medicine.medical_treatment Chronic pain medicine.disease Metastasis Transplantation Urokinase receptor 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Fibrinolysis Cutaneous melanoma medicine Cancer research 030211 gastroenterology & hepatology business medicine.drug |
| Zdroj: | Translational Medicine. 5:38-46 |
| ISSN: | 2410-5155 2311-4495 |
| Popis: | Background. Chronic pain is a pathologic process changing the whole body metabolism. Objective: determination of plasminogen regulators in tissues of cutaneous melanoma and in the skin tissues not associated with the tumor in female mice in the dynamics of the growth of experimental melanoma with chronic neurogenic pain. Design and methods . в16/F10 melanoma with chronic pain was reproduced in female С57вL/6 mice. Plasmin-alpha2-antiplasmin complex (PAP), urokinase (pro-uPA and uPA) and tissue (pro-tPA and tPA) plasminogen activators, the uPA (uPAR) receptor and serpin-1 (PAI-1) were determined by ELISA using standard test systems. Results were analyzed using the Statistica 10 program. Results. Chronic neurogenic pain was accompanied by significant changes in the fibrinolysis components in the skin of female С57вL/6 mice. After the в16/ F10 melanoma transplantation (1-3 weeks), skin and tumor tissues showed higher levels of рар and the uPAR receptor (p |
| Databáze: | OpenAIRE |
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