Fabrication of size-controlled SN-38 pure drug nanocrystals through an ultrasound-assisted reprecipitation method toward efficient drug delivery for cancer treatment

Autor:	Tsunenobu Onodera, Hitoshi Kasai, Yoshikazu Ikuta, Nozomi Saito, Yoshitaka Koseki, Farsai Taemaitree, Anh Thi Ngoc Dao, Ryuju Suzuki, Hidetoshi Oikawa
Rok vydání:	2021
Předmět:	Drug Materials science media_common.quotation_subject Nanoparticle Nanotechnology SN-38 Prodrug Condensed Matter Physics Small molecule Inorganic Chemistry chemistry.chemical_compound chemistry Nanofiber Drug delivery Materials Chemistry Irinotecan Hydrochloride media_common
Zdroj:	Journal of Crystal Growth. 572:126265
ISSN:	0022-0248
Popis:	Carrier-free drug nanoparticles are a promising drug delivery system for cancer therapy; however, the fabrication of nanoparticles composed of small molecule drugs is challenging. In this study, we fabricated pure drug nanocrystals, with nearly 100% of 7-ethyl-10-hydroxycamptothecin (SN-38) molecules, by using the ultrasound-assisted reprecipitation method. The rod-like nanocrystals with ca. 150 nm in a long axis were obtained through the ultrasound-assisted reprecipitation method, and the nanofibers were obtained without irradiation. Furthermore, the SN-38 nanocrystals exhibited considerably higher cytostatic activity against cancer cells than irinotecan hydrochloride, which is a clinically used prodrug of SN-38. These results demonstrate the potential of the ultrasound-assisted precipitation method as a powerful process to fabricate nanoparticles assembled using only small molecule drugs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7fb4bec8d6b6429dd8d7c3d29cf9bf0f https://doi.org/10.1016/j.jcrysgro.2021.126265 Zobrazit plný text záznamu Full Text from ScienceDirect