Ectopic fat and adipokines in metabolically benign overweight/obese women: The kronos early estrogen prevention study
| Autor: | Aileen P. McGinn, Matthew J. Budoff, Irfan Zeb, Unab I. Khan, Virginia M. Miller, Marcelle I. Cedars, Howard N. Hodis, Hugh S. Taylor, Eliot A. Brinton, JoAnn E. Manson, Rachel P. Wildman, Alexandra D. Ogorodnikova, Nanette Santoro, Frederick Naftolin, Rogerio A. Lobo, George R. Merriam, S M Harman |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Nutrition and Dietetics Leptin receptor Adiponectin business.industry Endocrinology Diabetes and Metabolism Medicine (miscellaneous) Adipose tissue Adipokine Overweight medicine.disease Obesity Endocrinology Internal medicine medicine Metabolic syndrome medicine.symptom business Body mass index |
| Zdroj: | Obesity. 21:1726-1733 |
| ISSN: | 1930-7381 |
| DOI: | 10.1002/oby.20200 |
| Popis: | Objective It is unclear why despite a comparable cardiometabolic risk profile, “metabolically benign” overweight/obese individuals show an elevated risk of cardiovascular disease compared to normal weight individuals. Design and Methods In cross-sectional analyses, we compared levels of ectopic fat (epicardial, pericardial, and hepatic fat) and adipokines (leptin, soluble leptin receptor, and high molecular weight [HMW] adiponectin) among metabolically benign (MBO) and at-risk overweight/obese (ARO), and metabolically benign normal weight (MBNW) women, screened for the Kronos Early Estrogen Prevention Study. We defined “metabolically benign” with ≤ 1, and “at-risk” with ≥2 components of the metabolic syndrome. Results Compared to MBO women, ARO women had significantly elevated odds of being in the top tertile of epicardial fat (OR: 1.76, 95% CI: 1.04-2.99), hepatic fat (OR: 1.90, 95% CI:1.12-3.24) and leptin (OR: 2.15, 95% CI: 1.23-3.76), and the bottom tertile of HMW-adiponectin (OR: 2.90, 95% CI: 1.62-5.19). Compared to MBNW women, MBO women had significantly higher odds of being in the top tertile of epicardial fat (OR: 5.17, 95% CI: 3.22-8.29), pericardial fat (OR: 9.27, 95% CI: 5.52-15.56) and hepatic fat (OR: 2.72, 95% CI: 1.77-4.19) and the bottom tertile of HMW adiponectin levels (OR: 2.51, 95% CI: 1.60-3.94). Conclusions Levels of ectopic fat and the adverse adipokine profile increase on a continuum of BMI, suggesting that the metabolically benign phenotype may be a transient state. |
| Databáze: | OpenAIRE |
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