PREVALENCE AND BACTERIOLOGICAL PROFILE OF NEONATAL SEPSIS IN NEWBORN INTENSIVE CARE UNIT OF A TERTIARY CARE HOSPITAL IN CENTRAL INDIA
| Autor: | Priyanka Shrivastava, Karan Bahadur Singh, Naikey Minarey, Vinod Kumar Gornale, Newton Ghosh |
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| Rok vydání: | 2019 |
| Předmět: |
Asphyxia
medicine.medical_specialty Respiratory distress Neonatal sepsis medicine.diagnostic_test business.industry Antibiotic sensitivity medicine.disease Intensive care unit law.invention Sepsis 03 medical and health sciences 0302 clinical medicine law 030225 pediatrics Internal medicine medicine Meconium aspiration syndrome Blood culture 030212 general & internal medicine medicine.symptom business |
| Zdroj: | Indian Journal of Child Health. :614-616 |
| ISSN: | 2349-6126 2349-6118 |
| DOI: | 10.32677/ijch.2019.v06.i11.010 |
| Popis: | Background: Neonatal sepsis (NS) is the most common cause of neonatal mortality responsible for about 30–50% of total neonatal deaths in developing countries. Surveillance of causative organisms and their antibiotic sensitivity pattern promotes the rational use of antibiotics and antibiotic stewardship. Objectives: The objectives of this study were to study the prevalence of NS in newborn intensive care unit of a tertiary hospital of Central India and to isolate the most common organism involved in sepsis in our setting. Materials and Methods: A retrospective study was conducted and relevant data of the neonates diagnosed with culture-positive sepsis were obtained from the case records during the period from February 2018 to February 2019. Culture-positive sepsis was defined as the isolation of bacterial pathogen from blood in neonates with clinical suspicion of sepsis. Results: A total of 223 neonates were enrolled. The major morbidities were hyperbilirubinemia (23.3%), birth asphyxia (14.3%), sepsis (53.8%), and respiratory distress (32.7%). The main causes of neonatal mortality were birth asphyxia (9.8%), prematurity (18.83%), sepsis (32.23), hyaline membrane disease (13.4%), and meconium aspiration syndrome (13.9%). A total of 120 cultures were found to be positive. The most common organism isolated was Staphylococcus aureus (39.3%) followed by Klebsiella pneumoniae (34%). Candida albicans was also isolated. Conclusion: Culture-positive NS accounted for 53.8% of all cases and is the major cause of mortality (32.28%) in the present study. Sepsis caused by Gram-positive bacteria was the most common among the neonates, although mortality was more in Gram-negative sepsis. Therefore, empirical regimen should be modified based on antibiogram of the isolates. |
| Databáze: | OpenAIRE |
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