ChemInform Abstract: Stereoselective Conjugate Addition of Aryl- and Alkenylboronic Acids to Acyclic γ,δ-Oxygen-Substituted α,β-Enoates

Autor:	Amaya Segura, Aurelio G. Csaky
Rok vydání:	2008
Předmět:	Addition reaction chemistry.chemical_compound Chemistry Group (periodic table) Stereochemistry Aryl Substituent chemistry.chemical_element Stereoselectivity General Medicine Oxygen Conjugate
Zdroj:	ChemInform. 39
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200804102
Popis:	The substrate-controlled RhI-catalyzed conjugate addition of aryl- and alkenylboronic acids to α,β-unsaturated esters which bear γ- and δ-oxygen substituents takes place in a highly anti diastereoselective fashion either when using γ-hydroxyl unprotected starting materials or when the γ-oxygen substituent is protected with a nonbulky group. The δ-oxygen substituent plays a role in the stereoselectivity of the reaction, and better results are obtained when this OH-group is protected.
Databáze:	OpenAIRE
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