| Autor: |
Shu Yuasa, Megumi Kabeya, Satoshi Hibi, Yuko Shirokawa, Chiaki Tokoro, Ryuichi Furuta, Seiji Nagao, Satoshi Kayukawa, Yoshiteru Tanaka, Kenji Ina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Journal of Analytical Oncology. 11:40-44 |
| ISSN: |
1927-7229 |
| Popis: |
Epidermal growth factor receptor (EGFR) has received significant attention for its therapeutic potential for pain relief. The relief of neuropathic pain after treatment with anti-EGFR antibodies or tyrosine kinase inhibitors has been previously described. However, few reports have investigated the association of cancer-related nociceptive pain or chronic chemical induced peripheral neuropathy with the analgesic effects of EGFR inhibition. Therefore, we conducted a retrospective survey of 191 patients with colorectal cancer receiving chemotherapy plus molecular targeting drugs to examine the analgesic effects of anti-EGFR antibodies against either cancer pain or oxaliplatin-induced peripheral neuropathy. We identified a significant difference in the improvement rates of nociceptive pain between panitumumab- and bevacizumab-treated patients (100% vs. 9.1%; p < 0.01), but not oxaliplatin-induced peripheral neuropathy. In conclusion, panitumumab may be effective at reducing cancer-related nociceptive pain. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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