| Popis: |
For four decades investigators have been using radio- and stable isotopes to help them understand aspects of mineral and trace element metabolism. In particular issues such as storage sites, absorption mechanisms, control mechanisms and control points, and excretion patterns have been exhaustively explored. In this period the focus of investigations has shifted from element to element as the overall metabolic profile of each element has become clearer. The seventies saw the investigation of zinc preoccupying kineticists and here taste and smell dysfunction, and tissue regeneration were issues at the focus of the studies. This chapter climaxes nearly thirty years of effort into the development and implementation of an accurate and reliable technique for the aggregation of models derived from multiple studies. The thrust of the eighties towards population-based modelling, as opposed to individual level analysis, promoted a review of this facility with the goals of establishing its correctness and improving its mode of access. |
