The various thyroid axis dysfunctions have cardiovascular consequences both in hyperthyroidism and in hypothyroidism. This cross-sectional study included hyperthyroid and hypothyroid female patients in whom uric acid and NT-proBNP were determined in relation to changes in clinical findings and some echocardiographic parameters. The results of our study suggest that NT-proBNP is a better predictor than uric acid, correlating with left ventricular diastolic dysfunction and systolic blood pressure variations.