Quasiallergy to β-lactam antibiotics as a predictor of therapeutic failures in the treatment of acute otitis media in children

Autor:	I. G. Andreeva, E. V. Luchkina, R. N. Mamleev
Rok vydání:	2020
Předmět:	medicine.medical_specialty chemistry.chemical_compound chemistry business.industry Acute otitis media medicine.drug_class Internal medicine Antibiotics Lactam Medicine business
Zdroj:	Practical medicine. 18:58-62
ISSN:	2307-3217 2072-1757
DOI:	10.32000/2072-1757-2020-6-58-62
Popis:	The wrong choice of starting antibiotic is one of the reasons for therapeutic failure in the treatment of acute otitis media in children. Currently, in Russia and around the world, macrolides are frequently used — drugs with low activity against Streptococcus pneumoniae. Prescription of macrolides in otiatrics is associated with the fear of allergies to β-lactam antibiotics (penicillins, cephalosporins), but this fear is highly hypertrophied and true anaphylaxis is extremely rare. Most often, there is a phenomenon of quasiallergy — a skin rash that is not associated with an allergy to an antibiotic. A detailed allergological history and the use of a proven algorithm of antibiotic therapy allow avoiding unnecessary frequent prescribing of macrolides and provide effective control over the focus of infection.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7f9242c6af2ee2d65cb97cb6030aec0b https://doi.org/10.32000/2072-1757-2020-6-58-62 Zobrazit plný text záznamu