Efficacy of hydrophilic or lipophilic emulsions containing Echinacea purpurea extract in treatment of different types of pruritus
| Autor: | Ana Kilic, Ulrich Knie, Anastasia Harder, Hubert Reich, Christoph Abels, Clarissa Masur |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
integumentary system Erythema business.industry Echinacea purpurea extract Echinacea purpurea root extract Dermatology Shampoo medicine.anatomical_structure Tolerability Scalp medicine medicine.symptom skin and connective tissue diseases business Antipruritic Chronic pruritus medicine.drug |
| Zdroj: | Clinical, Cosmetic and Investigational Dermatology. 11:591-602 |
| ISSN: | 1178-7015 |
| Popis: | Background Pruritus reduces quality of life and may occur at different sites of the body. To alleviate pruritus, lipid replenishing and rehydration of the skin is often unsatisfactory. Thus, products with additional antipruritic effects are needed. Objectives Antipruritic effects and cosmetic properties of two different emulsions, water-in-oil (w/o) or oil-in-water (o/w), and a shampoo containing a lipophilic Echinacea purpurea root extract (Ec.-extract) were assessed in adults suffering from pruritus. Methods Adults (n = 55) with pruritus of the body applied a w/o emulsion for 2 weeks. In a separate study, adults (n = 33) with a pruritic scalp applied an o/w-emulsion for 4 weeks. In a third study, shampoo (n = 34) was applied for 4 weeks. Objective (erythema, dryness, and papules) and subjective (intensity, duration, and burden of pruritus) parameters were assessed. Results Treatment with the w/o emulsion significantly reduced erythema and dryness (P < 0.0001) as well as pruritus (in 93% of participants) on the body. Treatment with the o/w-emulsion on the scalp significantly (P < 0.0001) reduced objective (erythema in 61% and dryness in 85% of participants) and subjective (85% of participants had reduced pruritus) parameters. Similar results in reduction of dryness (76% of participants) and pruritus (70 % of participants) were seen after 4 weeks of shampoo use. Conclusion Independent from the type of emulsion (w/o or o/w), cosmetic products containing a proprietary Ec.-extract significantly reduced objective and subjective parameters in adults suffering from acute or chronic pruritus exhibiting excellent tolerability. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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