Pharmacokinetic properties of zolpidem in elderly and young adults: possible modulation by testosterone in men
| Autor: | Hermann R. Ochs, Ronenn Roubenoff, David J. Greenblatt, Jerold S. Harmatz, Leah M. Hesse, Lisa L. von Moltke, Richard I. Shader, Joel O. Olubodun |
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| Rok vydání: | 2003 |
| Předmět: |
Pharmacology
medicine.medical_specialty Zolpidem medicine.drug_class Chemistry musculoskeletal neural and ocular physiology Zolpidem Tartrate Cmax Hypnotic Endocrinology Pharmacokinetics Oral administration Sedative Internal medicine medicine Pharmacology (medical) psychological phenomena and processes Testosterone medicine.drug |
| Zdroj: | British Journal of Clinical Pharmacology. 56:297-304 |
| ISSN: | 0306-5251 |
| Popis: | Aims The influence of ageing on the pharmacokinetics of zolpidem, an extensively prescribed hypnotic medication, was evaluated in healthy human volunteers. Methods A series of 16 elderly (age: 61–85 years) and 24 young (age: 22–42 years) volunteers received single 5 mg oral doses of zolpidem tartrate. Serum zolpidem concentrations were determined by HPLC with fluorescence detection in samples drawn during 8 h after dosage. The effect of testosterone on zolpidem biotransformation was evaluated in vitro using human liver microsomes. Possible induction of CYP3A protein expression and function was studied in cultured human hepatocytes. Results Among men, apparent oral clearance of zolpidem was decreased in elderly compared to young subjects (3.8 vs 11.0 ml min−1 kg−1, P |
| Databáze: | OpenAIRE |
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