La paraoxonase 1 : un marqueur de risque cardiovasculaire chez les jeunes diabétiques de type 1 ? (109 cas)

Autor:	Sonia Triki, Ilhem Hellara, Fadhel Najjar M, S. Chouchane, Fadoua Neffati, Neji Gueddiche M, Ons Fekih
Rok vydání:	2015
Předmět:	medicine.medical_specialty Type 1 diabetes biology business.industry Case-control study Paraoxonase General Medicine Diabetic angiopathy medicine.disease PON1 Gastroenterology Aryldialkylphosphatase Internal medicine medicine biology.protein Microalbuminuria business Dyslipidemia
Zdroj:	La Presse Médicale. 44:e185-e190
ISSN:	0755-4982
Popis:	OBJECTIVES We purpose to verify if paraoxonase 1 (PON1) activity may be a marker of cardiovascular risk in a young Tunisian population with type 1 diabetes (T1D). METHODS PON1 activity was measured by a kinetic method using paraoxon as substrate. The other parameters were determined by automated methods. RESULTS One hundred and nine children and adolescents with T1D and 97 healthy subjects were involved in this study. PON1 activity and PON1/HDL-cholesterol ratio were significantly decreased in diabetics (303 ± 174 vs. 372 ± 180 U/L and 221 ± 139 vs. 298 ± 20 1U/mmol, P=0.006, P=0.002, respectively) compared to controls. A significant increase in total cholesterol, LDL-c and microalbuminuria was observed in diabetics compared to controls. PON1 activity was decreased by 9.5% in patients with diabetes duration ≥ 6 years, by 28.4% for those with fasting glycemia ≥ 7 mmol/L (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7f8e8a750512d90bf048ae72bebd40a0 https://doi.org/10.1016/j.lpm.2014.10.020 Zobrazit plný text záznamu Full Text from ScienceDirect