New Modulators of NMDA-Receptors Based on Alkyne-Azide Click-Reaction Between 2-Aminothiophene-3-carboxylic Acids Esters and N-Propargyl-Containing Pharmacophores

Autor:	Vladimir V. Grigoriev, T. V. Goreva, V. B. Sokolov, A. Yu. Aksinenko, A. V. Gabrel’yan, T. A. Epishina
Rok vydání:	2020
Předmět:	chemistry.chemical_classification 010405 organic chemistry Alkyne General Chemistry 010402 general chemistry 01 natural sciences Combinatorial chemistry Cycloaddition 0104 chemical sciences chemistry.chemical_compound chemistry Click chemistry NMDA receptor Azide Pharmacophore Conjugate N-propargyl
Zdroj:	Russian Journal of General Chemistry. 90:32-38
ISSN:	1608-3350 1070-3632
DOI:	10.1134/s1070363220010053
Popis:	Copper-catalyzed alkyne-azide 1,3-dipolar cycloaddition of methyl esters of N-azidoacetyl-2-aminothiophene-3-carboxylic acids to N-propargyl-containing pharmacophores, resulting in the corresponding conjugates combined by 1,2,3-triazole-containing alkylene, was studied. The radioligand-binding experiments show a strong modulating effect of the synthesized compounds on neuronal NMDA receptors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7f8a09d51e44a93479d72b68d3c6b92b https://doi.org/10.1134/s1070363220010053 Zobrazit plný text záznamu Plný text ve formátu PDF