Direct and Derivative Spectrophotometric Determination of Zn(II) in Pharmaceuticals

Autor:	K. Sara Subudhi, K. Ashok Rao, S. Shivaramaiah S. Shivaramaiah, D. Sree Vani
Rok vydání:	2013
Předmět:	chemistry.chemical_classification Chromatography Trace Amounts Chemistry chemistry.chemical_element General Medicine Zinc Molar absorptivity Absorbance Acetic acid chemistry.chemical_compound Heterocyclic compound Salting out Sodium acetate
Zdroj:	Chemical Science Transactions. 2:513-523
ISSN:	2278-3318 2278-3458
DOI:	10.7598/cst2013.393
Popis:	Heterocyclic compound diamino and dihydroxy- pyramidine was synthesized and proposed as chelating agent for the determination of trace amounts of zinc. Zinc(II) forms the ripen-mango- colour complex with DADHP (Diamino dihydroxypyrimidine) in 1:3 stoichiometric ratio at pH-6 in acetic acid and sodium acetate buffer in the presence of pyrideniumchloride as salting out agent. The maximum absorbance is observed at 480 nm. The Beer's law is obeyed in the range of 1-6 µg. The molar absorptivity (e) and Sandell's sensitivity of the complex is 0.1484 x 10 4 L mol -1 cm -1 and 0.04545 µg cm -1 respectively. The method was successfully applied for the quantification of Zn(II) in pharmaceutical multi vitamin preparations in the presence of other trace elements. The statistical data evaluated reveals the sensitivity and accuracy of the method than the other methods reported.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7f876bc573b5d55dfad52973cc82afda https://doi.org/10.7598/cst2013.393 Zobrazit plný text záznamu