Hypercalcémie humorale révélant un lymphome malin non hodgkinien
| Autor: | Jérôme Desramé, Dominique Béchade, J.-P. Algayres, Stéphane Lecoules, T. Amezyane, L. Bordier, G Coutant, J.-S. Blade |
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| Rok vydání: | 2008 |
| Předmět: |
Abdominal pain
medicine.medical_specialty Chemotherapy business.industry Endocrinology Diabetes and Metabolism medicine.medical_treatment Metabolic disorder Cancer General Medicine medicine.disease Gastroenterology Lymphoma Endocrinology Internal medicine Concomitant Vitamin D and neurology Medicine medicine.symptom business Complication hormones hormone substitutes and hormone antagonists |
| Zdroj: | Annales d'Endocrinologie. 69:58-62 |
| ISSN: | 0003-4266 |
| DOI: | 10.1016/j.ando.2007.10.004 |
| Popis: | Introduction Hypercalcemia is a rare complication of non-Hodgkin lymphoma. Usually, hypercalcemia occurs late in the disease course, except for high-grade lymphoma. Most often hypercalcemia is related to excessive level of circulating PTH-rP or sometimes, 1,25(OH)2D3. Concomitant high plasmatic concentration of PTH-rP and 1,25(OH)2D3 is uncommon. Exegesis We report the case of a 82-year-old man who presented with abdominal pain and weight loss, leading to the diagnosis of diffuse large-B-cell lymphoma (high-grade lymphoma) associated with symptomatic hypercalcemia (3.21 mmol/l). PTH-rP and 1,25(OH)2D3 plasmatic levels were high. Calcium concentration was normalized with glucocorticoids and sequential chemotherapy. Conclusion This case report confirms that hypercalcemia, as consequence of excessive plasmatic level of PTH-rP secreted by tumoral cells, can occur early in the course of high-grade lymphoma. Glucocorticoids and chemotherapy are the best treatment options. |
| Databáze: | OpenAIRE |
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