A rare case of invasive melanoma likely arising from passenger melanocytes of a basal cell carcinoma
| Autor: | L. Brent Talbott, Hana Paladichuk |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Pathology Histology integumentary system Melanoma Cell Dermatology Biology medicine.disease Pathology and Forensic Medicine Lesion 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure 030220 oncology & carcinogenesis medicine Immunohistochemistry Histopathology Basal cell carcinoma Invasive Melanoma Epidermis medicine.symptom neoplasms |
| Zdroj: | Journal of Cutaneous Pathology. 47:1192-1195 |
| ISSN: | 1600-0560 0303-6987 |
| Popis: | Neoplasms consisting of different cell lineages within a single skin specimen are rare, yet well documented in the literature. However, to date, there appears to be no report of invasive melanoma arising directly from the passenger melanocytes of a basal cell carcinoma (BCC). We present a case of a 91-year-old male with a suspicious lesion on the ear. Histopathology and immunohistochemical staining revealed BCC closely intertwined with invasive melanoma that exhibited foci of chondroid differentiation. The melanoma appeared to arise from the benign-appearing passenger melanocytes of the BCC and lacked connection to the overlying epidermis or an in situ component. Multiple dermatopathologists reviewed the case and agreed that the most likely explanation for the histopathologic findings was that the invasive melanoma arose from the passenger melanocytes within the BCC. |
| Databáze: | OpenAIRE |
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