Correlation of rheoencephalography and laser Doppler flow: a rat study
| Autor: | Melissa Laird, Aaron A. Hall, Michael Bodo, Martin Baruch, Richard T. Mahon, Ryan L Sheppard, Shravalya Tirumala |
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| Rok vydání: | 2016 |
| Předmět: |
Receiver operating characteristic
business.industry Biomedical Engineering Biophysics Blood flow 030204 cardiovascular system & hematology Laser Doppler velocimetry 03 medical and health sciences Rheoencephalography 0302 clinical medicine Cerebral blood flow Anesthesia Medicine Autoregulation Surgical preparation Laser doppler flow business 030217 neurology & neurosurgery Biomedical engineering |
| Zdroj: | Journal of Electrical Bioimpedance. 7:55-58 |
| ISSN: | 1891-5469 |
| DOI: | 10.5617/jeb.2985 |
| Popis: | Measuring brain electrical impedance (rheoencephalography) is a potential technique for noninvasive, continuous neuro-monitoring of cerebral blood flow autoregulation in humans. In the present rat study, we compared changes in cerebral blood flow autoregulation during CO2 inhalation measured by rheoencephalography to changes measured by laser Doppler flowmetry, an invasive continuous monitoring modality. Our hypothesis was that both modalities would reflect cerebral blood flow autoregulation. Male Sprague-Dawley rats (n=28; 28 control and 82 CO2 challenges) were measured under anesthesia. The surgical preparation involved implantation of intracerebral REG electrodes and an LDF probe into the brain. Analog waveforms were stored in a computer. CO2 inhalation caused transient, simultaneous increases in the signals of both laser Doppler flow (171.99 ± 46.68 %) and rheoencephalography (329.88 ± 175.50%). These results showed a correlation between the two measured modalities; the area under the receiver operating characteristic curve was 0.8394. The similar results obtained by measurements made with laser Doppler flowmetry and rheoencephalography indicate that rheo-encephalography, like laser Doppler flowmetry, reflects cerebral blood flow autoregulation. Rheoencephalography therefore shows potential for use as a continuous neuro-monitoring technique. |
| Databáze: | OpenAIRE |
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