Preparation and crystal structure of hydrated crystalline complex of ciprofloxacin and copper tetrachloride

Autor:	T. D. Churilov, A. D. Vasil’ev, Maxim S. Molokeev, Nicolay N. Golovnev
Rok vydání:	2005
Předmět:	Hydrogen Hydrogen bond Low-barrier hydrogen bond Inorganic chemistry chemistry.chemical_element Protonation Crystal structure Hydrogen atom Inorganic Chemistry Crystallography chemistry Intramolecular force Materials Chemistry Molecule Physical and Theoretical Chemistry
Zdroj:	Journal of Structural Chemistry. 46:363-370
ISSN:	1573-8779 0022-4766
Popis:	Synthesis of a complex formed by ciprofloxacin (cfH) and copper(II) chloride is described; its crystal structure is reported and analyzed in comparison to related compounds. The obtained compound (cfH3)CuCl4·H2O (cfH32+ — double protonated cfH molecule) crystallizes as platelets of P21/c symmetry having the unit cell parameters a = 13.491(1) A, b = 11.0459(7) A, c = 16.299(1) A; β = 111.392(7)°. Carbonyl oxygen O(1) is protonated, and hydrogen atom combined with it forms an intramolecular hydrogen bond with carboxylic O(2) oxygen (O(1)⋯O(2) = 2.642(5) A). Terminal nitrogen atom N(3) of the piperazinyl group is also protonated, and two its hydrogen atoms participate in hydrogen bonds of N-H⋯Cl type. The structure also has hydrogen bonds O-H⋯O, O-H⋯Cl with the participation of water molecules which occupy hydrophilic channels. Molecular ions cfH32+ make couples with intrapair π⋯π interactions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7f4132b7090dff303ce974034ed2ce7f https://doi.org/10.1007/s10947-006-0055-8 Zobrazit plný text záznamu Plný text ve formátu PDF