Implications of resistin plasma levels in subjects undergoing coronary angiography
| Autor: | Stefan Pilz, Winfried März, Britta Wellnitz, Gisela Weihrauch, Bernhard O. Boehm, Bernhard R. Winkelmann, Ursula Seelhorst |
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| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
business.industry Endocrinology Diabetes and Metabolism nutritional and metabolic diseases Adipokine medicine.disease Coronary artery disease Endocrinology Insulin resistance Internal medicine Diabetes mellitus Medicine Resistin Risk factor Prospective cohort study business Body mass index hormones hormone substitutes and hormone antagonists |
| Zdroj: | Clinical Endocrinology. 66:380-386 |
| ISSN: | 1365-2265 0300-0664 |
| DOI: | 10.1111/j.1365-2265.2007.02743.x |
| Popis: | Summary Background The adipokine resistin, which is thought to serve as a link between obesity and insulin resistance, was recently shown to exert proatherosclerotic features. Objective Our study aimed to explore the involvement of resistin in cardiovascular disease by investigating the associations of resistin with angiographic coronary artery disease (CAD), cardiovascular risk factors and mortality. Design The Ludwigshafen Risk and Cardiovascular Health (LURIC) study is a prospective study of white subjects who had undergone coronary angiography. Patients and measurements Resistin levels were determined in 1162 subjects with (n = 911) and without (n = 251) angiographic CAD. During a mean follow-up period of 5·47 years, 198 deaths occurred among our probands. Results Resistin was positively correlated with C-reactive protein (CRP; r = 0·245, P |
| Databáze: | OpenAIRE |
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