A Homolog of Drosophila grainy head Is Essential for Epidermal Integrity in Mice

Autor:	Stephen M. Jane, Nikki R. Hislop, John M. Cunningham, Yoshikazu Uchida, Peter M. Elias, Alana Auden, Stephen B. Ting, Tomasz Wilanowski, Lin-Lin Zhao, Jacinta Caddy, Walter M. Holleran, Pritinder Kaur, Sarah Ellis
Rok vydání:	2005
Předmět:	Multidisciplinary integumentary system Tissue transglutaminase Anatomy Biology biology.organism_classification DNA-binding protein Epithelium Cell biology medicine.anatomical_structure Drosophilidae Gene expression biology.protein medicine Drosophila melanogaster Wound healing Transcription factor
Zdroj:	Science. 308:411-413
ISSN:	1095-9203 0036-8075
DOI:	10.1126/science.1107511
Popis:	The Drosophila cuticle is essential for maintaining the surface barrier defenses of the fly. Integral to cuticle resilience is the transcription factor grainy head , which regulates production of the enzyme required for covalent cross-linking of the cuticular structural components. We report that formation and maintenance of the epidermal barrier in mice are dependent on a mammalian homolog of grainy head, Grainy head-like 3 . Mice lacking this factor display defective skin barrier function and deficient wound repair, accompanied by reduced expression of transglutaminase 1, the key enzyme involved in cross-linking the structural components of the superficial epidermis. These findings suggest that the functional mechanisms involving protein cross-linking that maintain the epidermal barrier and induce tissue repair are conserved across 700 million years of evolution.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7f2ef40ce5a65b7515184d21ca706653 https://doi.org/10.1126/science.1107511 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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